Prescription Drug Abuse Statistics

Eye-opening prescription drug abuse statistics. Uncover the prevalence, consequences, and interventions to combat this growing concern.

Understanding Prescription Drug Abuse

Prescription drug abuse is a serious public health concern that involves the misuse or excessive use of prescription medications. It poses significant risks to individuals and communities alike. To gain a comprehensive understanding of prescription drug abuse, it is important to examine its definition, scope, prevalence, trends, and the consequences associated with this issue.

Definition and Scope

Prescription drug abuse refers to the use of prescription medications in a manner that deviates from the prescribed instructions or for non-medical purposes. This includes taking drugs without a prescription, taking larger doses than prescribed, using medications for recreational purposes, or using them to self-medicate (NIDA). It is important to note that even when taken as prescribed, certain medications can be addictive and should be used cautiously under the guidance of a healthcare professional.

The scope of prescription drug abuse extends across various age groups and demographics. It affects individuals of all backgrounds, but certain populations may be more susceptible to its risks, such as young adults aged 18 to 25. Adolescents and young adults may be particularly vulnerable to experimentation and misuse due to factors such as peer influence, easy access to medications, and a lack of awareness about the potential dangers associated with prescription drugs.

Prevalence and Trends

The prevalence of prescription drug abuse has been a cause for concern in recent years. According to the National Institute on Drug Abuse (NIDA), the percentage of adolescents reporting substance use has decreased significantly in 2021. However, it is important to remain vigilant as trends and patterns can vary over time.

Prescription drug abuse, particularly involving opioids, remains a significant issue. From 2019 to 2020, the rate of drug overdose deaths involving synthetic opioids, excluding methadone, increased by 38.4% in the United States. Opioid overdoses accounted for approximately 70% of all drug overdose deaths in the United States in 2019 (CDC). These statistics highlight the urgent need for comprehensive strategies to address prescription drug abuse.

Consequences of Prescription Drug Abuse

Prescription drug abuse can have severe consequences for individuals and society as a whole. The misuse of prescription medications can lead to physical and psychological dependence, overdose, and even death. In the United States alone, nearly 500,000 individuals died from opioid overdoses from 1999 to 2019.

The consequences of prescription drug abuse extend beyond the individual. Communities face the burden of increased healthcare costs, strain on public resources, and the societal impact of addiction. Addressing prescription drug abuse requires a comprehensive approach that involves prevention, intervention, treatment, and ongoing support for those affected.

Understanding the definition, prevalence, and consequences of prescription drug abuse is essential for developing effective strategies to combat this issue. By raising awareness, implementing evidence-based interventions, and promoting responsible prescribing practices, we can work towards reducing the harm caused by prescription drug abuse and improving the overall well-being of individuals and communities.

Types of Abused Prescription Drugs

When it comes to prescription drug abuse, the most commonly abused drugs fall into three main classes: opioids, central nervous system (CNS) depressants, and stimulants. Each class of drugs poses its own risks and potential consequences.

Opioids

Opioids are powerful pain-relieving medications that can be highly addictive. Some commonly abused opioids include oxycodone, hydrocodone, and fentanyl. These drugs work by binding to opioid receptors in the brain, effectively reducing pain perception. However, they also produce a sense of euphoria, which can lead to misuse and abuse.

Abusing opioids can have severe consequences. It can result in mood and behavior changes, impaired thinking, and respiratory problems. The risks are further compounded when opioids are combined with other substances, such as alcohol, antihistamines, or CNS depressants. Such combinations can lead to dangerous interactions and increase the risk of overdose and death (KidsHealth).

Central Nervous System (CNS) Depressants

CNS depressants, also known as sedatives or tranquilizers, are medications prescribed to treat anxiety, sleep disorders, and seizures. Examples of CNS depressants include benzodiazepines (e.g., Xanax, Valium) and barbiturates. These drugs work by slowing down brain activity, promoting relaxation and calmness.

Abusing CNS depressants can have serious consequences. It can result in drowsiness, confusion, impaired coordination, slurred speech, slowed breathing, and even seizures if abruptly stopped. Mixing CNS depressants with other substances, especially alcohol, can intensify these effects and increase the risk of overdose and other complications.

Stimulants

Stimulants are medications prescribed to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Commonly abused stimulants include amphetamines (e.g., Adderall) and methylphenidate (e.g., Ritalin). These drugs work by increasing dopamine and norepinephrine levels in the brain, improving focus, attention, and alertness.

Abusing stimulants can lead to various health risks. It can cause heart problems, seizures, panic attacks, paranoia, and even aggressive or violent behavior. Mixing stimulants with other medications, including over-the-counter drugs, can further increase the risks and potential complications.

Understanding the different classes of prescription drugs commonly abused is essential in recognizing the potential risks and consequences associated with their misuse. It's important to remember that prescription drug misuse is second only to marijuana use as the nation's most commonly used illicit drug, highlighting the significance of addressing this public health concern.

Risk Factors for Prescription Drug Abuse

Understanding the risk factors associated with prescription drug abuse is crucial in identifying those who may be more susceptible to this concerning issue. Several factors can contribute to an individual's likelihood of engaging in prescription drug abuse, including age and gender, mental health conditions, and a history of substance abuse.

Age and Gender

Prescription drug abuse is particularly prevalent among young adults aged 18 to 25, with approximately 1.8 million young adults reporting nonmedical use of prescription drugs in the past year. Among youth aged 12 to 17, nonmedical use of prescription drugs ranks as the second most common category of illicit drug use, following marijuana use (NIDA). Young adults between 18 to 25 years of age have the highest prevalence of illicit use of prescription drugs compared to other age groups, with high rates of lifetime, past-year, and past-month use of any illicit drug (PMC).

Gender can also play a role in prescription drug abuse. U.S. college men are generally more likely than college women to report nonmedical use of prescription stimulants. However, it is important to note that prescription drug abuse can affect individuals of all ages and genders.

Mental Health Conditions

Individuals with mental health conditions are at an increased risk of prescription drug abuse. Studies have shown that those who abuse prescription medications are more likely to have a history of past-year alcohol use disorder, past-year illicit drug use disorder, and past-year major depressive episode compared to those who do not abuse prescription drugs (NIDA). Mental health conditions can contribute to self-medication practices, where individuals may misuse prescription drugs to alleviate symptoms or cope with emotional distress.

History of Substance Abuse

A history of substance abuse is a significant risk factor for prescription drug abuse. Those who have previously engaged in substance abuse, whether with illicit drugs or alcohol, are more susceptible to developing a pattern of prescription drug misuse. Additionally, individuals with a history of substance abuse may have increased access to prescription drugs through social networks or previous encounters with healthcare professionals.

It is important to note that risk factors do not guarantee that an individual will engage in prescription drug abuse. However, understanding these factors can help healthcare professionals and individuals themselves recognize potential vulnerabilities and take proactive steps to prevent or address prescription drug abuse.

By identifying these risk factors, healthcare providers, educators, and communities can implement targeted prevention strategies, early intervention programs, and effective treatment options to mitigate the risks associated with prescription drug abuse.

Causes and Motivations for Prescription Drug Abuse

Prescription drug abuse can stem from various causes and motivations. Understanding these factors is essential in addressing the issue effectively. Let's explore three common causes and motivations for prescription drug abuse: pain relief, recreational use, and self-medication.

Pain Relief

One significant factor that may lead individuals to abuse prescription drugs is the desire to alleviate physical pain. In 2015, approximately 11.5 million adults in the United States misused prescription pain relievers at least once in the past year, accounting for 4.7 percent of all adults or 12.5 percent of adults who used pain relievers during that period.

For some individuals, the misuse of prescription pain relievers provides temporary relief from chronic pain or discomfort. However, it's crucial to recognize that using these medications without proper medical guidance can lead to serious consequences, including addiction and other health risks.

Recreational Use

Another motivation for prescription drug abuse is the desire to experience the pleasurable effects produced by certain medications. In some cases, individuals may misuse prescription drugs solely for recreational purposes, seeking a sense of euphoria or altered state of mind.

While prescription drugs may have legitimate therapeutic uses when prescribed by a healthcare professional, using them recreationally can be highly dangerous. It's important to remember that these medications are formulated for specific medical conditions and should only be used as directed by a healthcare provider.

Self-Medication

Self-medication is another common cause of prescription drug abuse. Some individuals may turn to prescription drugs as a means of coping with emotional or psychological distress. This can include using medications to alleviate anxiety, depression, or other mental health conditions.

In 2015, approximately 5.7 million adults in the United States misused prescription tranquilizers at least once in the past year, representing 2.3 percent of all adults or 14.8 percent of adults who used tranquilizers during that period (SAMHSA). The most common reasons for misusing prescription tranquilizers were to relax or relieve tension (46.2 percent) and to help with sleep (21.2 percent).

It's important to note that self-medication with prescription drugs can be risky. It's always advisable to seek professional help from a healthcare provider or mental health specialist to address underlying issues and receive appropriate treatment.

Understanding the causes and motivations behind prescription drug abuse is essential in developing effective strategies for prevention, intervention, and treatment. By addressing these factors, healthcare professionals and policymakers can work towards mitigating the risks associated with prescription drug misuse and promoting the overall well-being of individuals.

Prescription Drug Misuse vs. Prescription Drug Abuse

When discussing the misuse and abuse of prescription drugs, it's important to understand the definitions and differences between these terms, as well as the potential dangers and consequences associated with each.

Definitions and Differences

Prescription drug misuse refers to the use of prescription medications in a manner that is different from what is prescribed by a healthcare professional. This can include taking medications in higher doses, taking them more frequently, or using them for reasons other than their intended purpose. Misuse can occur even when the medication is obtained legally with a prescription.

On the other hand, prescription drug abuse involves the intentional and non-medical use of prescription medications for the purpose of achieving a euphoric or mind-altering effect. It often involves the use of medications without a prescription or in a manner not prescribed by a healthcare professional. Abuse can lead to serious health consequences and may develop into a substance use disorder.

While prescription drug misuse and abuse are related, it's important to note that not all instances of misuse necessarily indicate abuse. Some individuals may engage in occasional or unintentional misuse without developing a full-blown substance use disorder. However, continued misuse can increase the risk of developing an addiction and experiencing harmful effects.

Potential Dangers and Consequences

Both prescription drug misuse and abuse carry significant risks and potential consequences. Some of the dangers associated with these behaviors include:

  • Health complications: Misusing or abusing prescription drugs can lead to a range of negative health effects, such as respiratory depression, cardiovascular problems, liver damage, and cognitive impairments. The specific risks vary depending on the type of medication being misused or abused.
  • Addiction and dependence: Prolonged misuse or abuse of prescription drugs can lead to addiction, characterized by a compulsive need to use the drug despite negative consequences. Dependence can also develop, leading to withdrawal symptoms when the drug is discontinued.
  • Overdose: Prescription drug misuse and abuse can significantly increase the risk of overdose, which can be life-threatening. Overdose occurs when an individual takes more medication than their body can handle, leading to severe respiratory depression, organ failure, and even death.
  • Legal consequences: Engaging in prescription drug misuse or abuse can have legal ramifications, as it often involves the unauthorized possession or distribution of controlled substances. Legal penalties can vary depending on the jurisdiction and the specific circumstances.

To address the dangers and consequences of prescription drug misuse and abuse, it is crucial to raise awareness, implement effective prevention strategies, and provide access to appropriate treatment and recovery options. Healthcare providers play a vital role in promoting responsible prescribing practices, screening patients for potential substance abuse issues, and referring individuals to treatment when needed.

By understanding the definitions, differences, and potential risks associated with prescription drug misuse and abuse, individuals and communities can work together to combat this public health issue and promote safer and more responsible medication use.

Prevention and Intervention Strategies

To combat prescription drug abuse, various prevention and intervention strategies have been implemented. These strategies focus on addressing the misuse of prescription drugs and raising awareness about the associated risks. Three key strategies are prescription drug monitoring programs (PDMPs), education and awareness campaigns, and access and disposal strategies.

Prescription Drug Monitoring Programs (PDMPs)

Prescription drug monitoring programs (PDMPs) are state-run electronic databases that track the prescribing and dispensing of controlled substances. PDMPs provide healthcare providers with access to a patient's prescription history, enabling them to identify potential cases of misuse or diversion. PDMPs have been associated with lower rates of opioid prescribing and overdose in some states, although research regarding their impact is currently mixed.

PDMPs allow healthcare providers to make more informed decisions when prescribing medications, helping to prevent overprescribing and identify patients who may be at risk for substance abuse. By promoting responsible prescribing practices, PDMPs play a crucial role in reducing prescription drug abuse.

Education and Awareness Campaigns

Education and awareness campaigns are vital in preventing prescription drug abuse. These campaigns aim to inform the general public, healthcare professionals, and patients about the risks associated with prescription drug misuse. They also provide information on safe medication storage, proper disposal methods, and the signs of substance abuse.

Government agencies, nonprofit organizations, and healthcare institutions collaborate to develop educational materials, online resources, and community outreach programs. These campaigns emphasize the importance of following prescribed dosage instructions, never sharing prescription medications, and seeking help for substance abuse. By increasing awareness and knowledge, these campaigns strive to prevent the misuse of prescription drugs.

Access and Disposal Strategies

Access and disposal strategies focus on controlling the availability of prescription drugs and providing safe and convenient methods for their disposal. These strategies aim to reduce the potential for diversion and misuse of medications.

To control access, there have been federal initiatives to address opioid misuse, addiction, and overdose. Efforts include the National Institutes of Health's Helping End Addiction Long-term (HEAL) Initiative and the CDC Guideline for Prescribing Opioids for Chronic Pain issued in 2016. These initiatives provide guidelines for healthcare providers to ensure responsible prescribing practices and reduce the likelihood of overprescribing opioids.

Regarding disposal, proper medication disposal methods are encouraged to prevent the diversion of unused medications. Many communities have established medication take-back programs, allowing individuals to safely dispose of their unused medications at designated locations. Additionally, guidelines have been provided by the FDA on how to properly dispose of unused prescription drugs at home, such as mixing them with undesirable substances (like coffee grounds) and sealing them in a secure container before disposal.

By implementing access and disposal strategies, individuals are less likely to have easy access to prescription drugs that are not intended for them, reducing the likelihood of abuse and diversion.

Prevention and intervention strategies play a crucial role in addressing prescription drug abuse. Through the implementation of PDMPs, education and awareness campaigns, and access and disposal strategies, communities can work towards reducing the misuse and diversion of prescription medications and promoting safer practices for medication use.

Treatment and Recovery Options

When it comes to addressing prescription drug abuse, there are various treatment and recovery options available. These options aim to help individuals overcome addiction, manage withdrawal symptoms, and support long-term recovery. Some of the common treatment and recovery options include detoxification and withdrawal management, behavioral therapies, and medication-assisted treatment (MAT).

Detoxification and Withdrawal Management

Detoxification is often the first step in treating prescription drug abuse. This process involves removing the drug from the individual's system and managing the associated withdrawal symptoms. Detoxification can be done in an inpatient or outpatient setting, depending on the severity of the addiction and the individual's specific needs.

During detoxification, medical professionals closely monitor and support the individual as their body adjusts to the absence of the drug. Medications may be prescribed to alleviate withdrawal symptoms and ensure a safe and comfortable detoxification process. It's important to note that detoxification alone is not sufficient to address addiction and should be followed by further treatment and support.

Behavioral Therapies

Behavioral therapies play a crucial role in the treatment of prescription drug abuse. These therapies aim to address the underlying causes of addiction, modify destructive behaviors, and develop healthy coping mechanisms. Behavioral therapies are often conducted in individual, group, or family settings, and may include:

  • Cognitive-behavioral therapy (CBT): This therapy helps individuals identify and change negative thoughts and behaviors associated with drug abuse. It focuses on developing healthier patterns of thinking and developing effective strategies to manage cravings and triggers.
  • Contingency management: This therapy provides incentives, such as rewards or privileges, for individuals who abstain from drug use. It helps reinforce positive behaviors and motivate individuals to stay on the path of recovery.
  • Motivational interviewing: This therapy aims to increase an individual's motivation to change their addictive behaviors. It involves collaborative conversations that help individuals explore their ambivalence towards drug use and develop internal motivation for change.

Behavioral therapies are tailored to the individual's needs and may be combined with other treatment approaches for comprehensive care.

Medication-Assisted Treatment (MAT)

Medication-assisted treatment (MAT) combines medications with behavioral therapies to address prescription drug abuse. MAT is particularly effective for opioid addiction, but can also be used for other substances. It involves the use of FDA-approved medications, such as methadone, buprenorphine, and naltrexone, in combination with counseling and behavioral therapies.

These medications help to reduce cravings, alleviate withdrawal symptoms, and normalize brain function, allowing individuals to focus on their recovery. MAT is typically provided in specialized treatment programs under the supervision of healthcare professionals. It has been shown to improve treatment outcomes, reduce the risk of relapse, and support long-term recovery.

It's important to note that treatment and recovery options should be tailored to each individual's unique circumstances and needs. A comprehensive approach that combines multiple strategies, including detoxification, behavioral therapies, and medication-assisted treatment, can provide the best chances of successful recovery from prescription drug abuse. Seeking professional help and support is crucial for individuals struggling with prescription drug abuse to regain control of their lives and achieve lasting recovery.

The Role of Healthcare Providers

In the fight against prescription drug abuse, healthcare providers play a crucial role in preventing misuse, identifying individuals at risk, and facilitating appropriate treatment. By implementing responsible prescribing practices, conducting thorough screening and assessments, and facilitating referrals to treatment, healthcare providers can make a significant impact in addressing prescription drug abuse.

Responsible Prescribing Practices

Healthcare providers have a responsibility to ensure the safe and appropriate use of prescription medications. This includes following evidence-based guidelines, such as the CDC Guideline for Prescribing Opioids for Chronic Pain, which provides recommendations for healthcare providers in managing chronic pain while minimizing the risk of opioid misuse and addiction. In 2019, the CDC issued an advisory against misapplication of opioid guideline recommendations, emphasizing the need for individualized care and considering patient safety.

Responsible prescribing practices also involve monitoring patients' medication use through prescription drug monitoring programs (PDMPs). These state-run electronic databases track prescription drug dispensing to identify potential misuse or diversion. While research on the impact of PDMPs is mixed, they have been associated with lower rates of opioid prescribing and overdose in some states. These programs can help healthcare providers make informed decisions when prescribing medications, especially opioids.

Screening and Assessment

Screening and assessment are crucial steps in identifying individuals at risk of prescription drug abuse. Healthcare providers should routinely screen patients for substance use disorders, mental health conditions, and history of substance abuse. This can be done through validated screening tools and comprehensive interviews.

Screening for substance use disorders and mental health conditions allows healthcare providers to identify individuals who may be more susceptible to prescription drug abuse. Early detection enables healthcare providers to intervene and provide appropriate support and treatment options. Additionally, healthcare providers should evaluate patients' pain levels, medical history, and previous treatments to make informed decisions about prescribing medications.

Referral to Treatment

When healthcare providers suspect or identify prescription drug abuse in their patients, it is crucial to facilitate referrals to treatment. Referral options may include detoxification and withdrawal management programs, behavioral therapies, and medication-assisted treatment (MAT).

Detoxification and withdrawal management programs help individuals safely navigate the process of discontinuing drug use. These programs provide medical supervision and support to manage withdrawal symptoms and minimize the risk of complications.

Behavioral therapies, such as cognitive-behavioral therapy (CBT) and contingency management, are effective in addressing the underlying causes and behaviors associated with prescription drug abuse. These therapies help individuals develop coping mechanisms, improve problem-solving skills, and promote positive behavioral changes.

Medication-assisted treatment (MAT) combines medication, such as buprenorphine, methadone, or naltrexone, with behavioral therapies to treat opioid use disorders. MAT has been shown to be effective in reducing opioid use, overdose, and mortality rates.

By actively engaging in responsible prescribing practices, conducting thorough screenings and assessments, and facilitating referrals to treatment, healthcare providers can make a significant difference in reducing prescription drug abuse and promoting the overall well-being of their patients. Collaborative efforts between healthcare providers, policymakers, and public health initiatives are essential for addressing this complex issue.

Public Health Initiatives and Policies

Efforts to address prescription drug abuse have been a priority for public health organizations and policymakers. National initiatives, regulations, and collaborative approaches are being implemented to combat the issue and reduce the prevalence of prescription drug abuse.

National Efforts to Address Prescription Drug Abuse

The federal government has taken significant steps to address the problem of prescription drug abuse. In 2015, initiatives were initiated to reduce overdose and prevent opioid use disorders. These efforts include the National Institutes of Health's Helping End Addiction Long-term (HEAL) Initiative and the CDC Guideline for Prescribing Opioids for Chronic Pain issued in 2016.

These efforts aim to improve prescribing practices, increase access to treatment for substance use disorders, and enhance public education on the risks associated with prescription drug abuse. By coordinating federal resources and implementing evidence-based strategies, these national initiatives strive to make a significant impact on the opioid crisis.

Regulations and Legislation

Regulations and legislation play a crucial role in addressing prescription drug abuse. The CDC issued an advisory in 2019 against misapplication of opioid guideline recommendations due to inconsistent policies and practices. In the same year, the U.S. Department of Health and Human Services (HHS) provided opioid tapering guidance for clinicians considering reducing opioid therapy for individuals with chronic pain. The CDC later updated their guidance with opioid tapering recommendations for patient safety.

Additionally, abuse-deterrent formulations (ADF) for opioids have been developed by manufacturers to deter misuse. These formulations aim to prevent snorting or injection of opioids and have demonstrated a decrease in the illicit value of drugs. The FDA has also encouraged the development of ADF stimulants. These regulatory measures contribute to reducing the potential for misuse and abuse of prescription drugs.

Collaborative Approaches to Prevention

Collaboration among various stakeholders is essential in tackling prescription drug abuse. Public health organizations, healthcare providers, law enforcement agencies, community groups, and educational institutions come together to develop and implement prevention strategies.

One approach is the implementation of Prescription Drug Monitoring Programs (PDMPs), state-run electronic databases that track controlled substance prescriptions. PDMPs have been associated with lower rates of opioid prescribing and overdose in some states. However, the impact of PDMPs is still subject to ongoing research and evaluation.

Education and awareness campaigns are also vital in preventing prescription drug abuse. These initiatives aim to educate healthcare providers, patients, and the general public about the dangers of prescription drug misuse and the importance of responsible medication use. By promoting awareness and encouraging safe practices, these campaigns contribute to reducing the prevalence of prescription drug abuse.

Furthermore, access and disposal strategies are being implemented to ensure the safe storage and proper disposal of prescription medications. These efforts aim to prevent unintentional access to prescription drugs, especially by children and individuals without a legitimate medical need. By providing convenient and secure methods for medication disposal, the risk of diversion and misuse can be minimized.

Through collaborative approaches that involve a range of stakeholders, public health initiatives strive to prevent prescription drug abuse and promote the responsible use of medications. These efforts encompass regulations, educational campaigns, and strategies to improve access to treatment and disposal options. By addressing the issue comprehensively, the goal is to protect individuals from the harmful consequences of prescription drug abuse and promote healthier communities.

Prescription Drug Abuse Statistics

Understanding the prevalence and scope of prescription drug abuse is crucial in addressing this significant public health issue. This section provides an overview of the statistics related to prescription drug abuse.

Opioids

Prescription opioid misuse is a major concern in the United States. In 2015, approximately 11.5 million adults misused prescription pain relievers at least once in the past year, representing 4.7 percent of all adults or 12.5 percent of adults who used pain relievers during that period. The misuse of prescription opioids can lead to serious health consequences, including addiction and overdose.

Central Nervous System (CNS) Depressants

Prescription tranquilizers, which are CNS depressants, are also commonly misused. Around 5.7 million adults in the United States misused prescription tranquilizers at least once in the past year, which accounts for 2.3 percent of all adults or 14.8 percent of adults who used tranquilizers during that time (SAMHSA). Misusing prescription tranquilizers can have detrimental effects on an individual's physical and mental health.

Stimulants

While less prevalent than opioids and CNS depressants, prescription stimulant misuse is still a concern. According to available data, the misuse of prescription stimulants among adults is less common. However, it's important to note that misuse can still have serious consequences for individuals who engage in this behavior.

The reasons behind prescription drug abuse vary among individuals. For pain relievers, the most commonly identified reason for misuse among adults is to relieve physical pain (63.4 percent), followed by using them to feel good or get high (11.7 percent) and to relax or relieve tension (10.9 percent). For tranquilizers, the primary motivations for misuse are to relax or relieve tension (46.2 percent) and to help with sleep (21.2 percent).

These statistics highlight the need for effective prevention, intervention, and treatment strategies to address prescription drug abuse. By increasing awareness, promoting responsible prescribing practices, and implementing comprehensive public health initiatives, we can work towards reducing the incidence of prescription drug abuse and its associated harms.

Sources

SAMHSA

PMC

NIDA